San Domino Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to CA $1,096 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Ready to book your vacation to San Domino?

 

Choose your dates

San Domino Hotel Deals

Eden

Eden

3 out of 5
Via Garibaldi 1 - Isolotto Di San Domino, Tremiti Islands, FG
Fully refundableReserve now, pay when you stay
The price is CA $142 per night from Sep 16 to Sep 17
CA $142
CA $156 total
Sep 16 - Sep 17
includes taxes & fees
8.2/10 Very Good! (219 reviews)
"Friendly staff, great location. Katia at Reception was amazing"

Reviewed on Aug. 2, 2025

Eden
Hotel Kyrie Isole Tremiti

Hotel Kyrie Isole Tremiti

3 out of 5
Isole Tremiti, San Domino, Tremiti Islands, FG
Fully refundableReserve now, pay when you stay
The price is CA $122 per night from Sep 14 to Sep 15
CA $122
CA $134 total
Sep 14 - Sep 15
includes taxes & fees
8/10 Very Good! (127 reviews)
"The hotel is in a very good location, walking distance (10-15mins) from the main square with shops, restaurants and a grocery shop. The hotel is in a beautiful scenery, up on the top of the island, with complimentary (free for guests of the hotel) frequent and very convenient shuttle transport from ..."

Reviewed on Jul. 13, 2024

Hotel Kyrie Isole Tremiti
L'ISOLA DEI SAPORI BOUTIQUE HOTEL

L'ISOLA DEI SAPORI BOUTIQUE HOTEL

STRADA PROVINCIALE 41 KM 34,00, Cagnano Varano, FG
The price is CA $186 per night from Sep 8 to Sep 9
CA $186
CA $204 total
Sep 8 - Sep 9
includes taxes & fees
9.2/10 Wonderful! (15 reviews)
"The owner was so kind and friendly."

Reviewed on Jul. 26, 2025

L'ISOLA DEI SAPORI BOUTIQUE HOTEL
See all 23 properties in San Domino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a San Domino vacation package cost?
Browse and book everything in one place with our San Domino vacation packages, which start from just . Handpick the hotels and flights that suit your plans. Then, add on a couple of sightseeing activities to cap off your unique adventure.
How do I get a cheap travel package to San Domino?
Booking a flight and hotel together with Expedia won't just save you time — it'll save you a few dollars too. A San Domino vacation package makes it a cinch to organize the perfect trip. With more than 550 airlines throughout the world to select from, finding flights that fit your busy schedule won't be a hassle. On top of that, we have over 1,000,000 hotel options globally to select from. Now that's choice! Whatever your budget, Expedia will help show you the world.
How far in advance should I book my San Domino vacation?
While prices change from time to time, we generally advise booking your seats as early as possible. Most international fares are available on Expedia up to a year in advance. If circumstances have left you booking last minute, you may still get lucky. Low prices to San Domino sometimes occur just weeks before departure.
What does an Expedia San Domino travel package include?
It comes down to what you want. If you're traveling by yourself, you might decide to bundle hotels and flights. Bringing the entire family to San Domino? A travel package including flights, hotels and rental cars might be a better fit. Expedia gives you the flexibility to tailor-make your travel package.
What should I know before booking a San Domino travel package?
You'll score terrific savings when you combine your hotels, flights and rental cars into a travel package. Plus, booking everything together just makes things easier. So why waste time or money? Whether you're putting together a luxury city stay with your love or a budget family adventure, browse our package deals today.
Can I choose my airline with a San Domino Expedia vacation package?
Yes, of course. We have more than 550 airline partners worldwide, so opt for the carrier that matches your budget needs.
If I'm not able to travel, can I cancel my San Domino vacation package?
Don't worry if you're rethinking your San Domino vacation package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it at no cost. However, bookings made more than 24 hours ago may incur a fee from your airline, hotel or car rental company. We understand life can throw the occasional spanner in the works, so look up our Customer Service Portal if that happens. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.